Our Approach
Biagon creates solutions to empower drug developers during lead optimization for GPCR-targeting campaigns. Our Technology unveils mechanisms of activation and predicts the signaling efficacy of GPCR ligands.
How it Works
Our patent-pending approach discovers the conformational space of a specific GPCR target and uncovers the molecular mechanisms of agonism, partial agonism, biased agonism, antagonism, inverse agonism, etc. From studying the conformational space, we can accurately predict the signaling efficacy (Emax values), for multiple signaling pathways. We strive to push campaigns towards the desired signaling profile and maximized therapeutic outcomes.
Research Preprint: https://www.biorxiv.org/content/10.1101/2024.04.03.588021v1
